Normally, when a man is sexually aroused, the arteries in the penis relax and widen, allowing more blood to flow into the tissues of penis. As the arteries in the penis expand and harden, the veins that carry blood away from the penis become compressed, trapping the blood in the penis. This leads to enlargement, rigidity and ultimately in an erection of penis.

MECHANISM OF ACTION: The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP) producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood...

The erection goes away, once the sexual encounter is over. In case of an ED sufferer, improper functioning of the nerves or blood vessels associated with the erection process cause inability in getting or maintaining an erection. Kamagra, by its action, increases blood flow leading to erection.

Kamagra jelly is absorbed quickly into the bloodstream, with absorption moderately slowed when taken with a large, fatty meal, reducing the effectiveness. The maximum effect is usually observed about an hour after taking the tablet, lasting up to four hours, however, the effect gradually diminishes after two hours. Kamagra does NOT work without stimulation. A common misconception is that Kamagra itself causes the penis to become rigid. Kamagra oral jelly would actually have NO effect in the absence of arousal, and the success rate holds at about 75% with stimulation.

After Kamagra enters the bloodstream, it works by inhibiting an enzyme, phosphodiesterase 5 (PDE5), that is found almost expressly in the penis. During sexual arousal, cyclic guanosine monophosphate (cGMP) is produced, which causes a penile erection. PDE5 inactivates cGMP, which is a normal function of time. For men with no erectile dysfunction, this is a good thing! With men who have ED, PDE5 is a substance that prevents an erection. With PDE5 out of the way, cGMP is allowed to remain, doing it’s job of allowing greater blood flow into the penis, to sustain an erection. Use of Kamagra oral jelly does NOT protect against sexually transmitted diseases such as HIV, Hepatitis B, gonorrhea, syphilis, chlamydia, or herpes. etc.

MECHANISM OF ACTION (continued): Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but enhances the effect of NO (Nitric oxide) by inhibiting phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildenafil causes increased levels of cGMP in the corpus cavernosum resulting in smooth muscle relaxation and inflow of blood to the corpus.

Basically sildenafil relaxes the blood vessels in the penis, allowing more blood to enter to achieve and maintain an erection.